Pareto-Improving Optimal Capital and Labor Taxes

We study Pareto-optimal scal policy in a model with agents who are heterogeneous in their labor productivity and wealth. We show a natural modi cation of the standard Ramsey problem to guarantee that long-run capital taxes are zero. We focus on Paretoimproving policies and we nd that a gradual reform is crucial in achieving a Pareto improvement: labor taxes should be cut and capital taxes should remain high for a very long time before reaching zero. Therefore, the long-run optimal tax mix is the opposite of the short- and medium-run one. This policy redistributes wealth in favor of workers so that all agents bene t, and it favors quick capital growth after the reform. The labor tax cut is nanced by de cits which lead to a positive level of government debt in the long run, reversing the standard prediction that the government accumulates savings in models with optimal capital taxes. The welfare bene ts from the tax reform are relatively large and they can be shifted entirely to capitalists or workers by varying the length of the transition. We address a number of technical issues such as su ciency of Lagrangian solutions in a Ramsey problem, relation of Pareto-improving allocations with welfare functions, asymptotic behavior, and solution algorithms

Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment

Despite the ongoing “war on cancer,” cancer remains one of the major causes of human morbidity and mortality. A new paradigm of targeted therapies holds the most promise for the future, making identification of tumor-specific therapeutic targets of prime importance. ERBB2/HER2, best known for its role in breast cancer tumorigenesis, can be targeted by two types of pharmacological manipulation: antibody therapy against the extracellular receptor domain and small molecule compounds against the intracellular tyrosine kinase domain. Aberrant activation of ERBB2 by gene amplification has been shown to participate in the pathophysiology of breast, ovarian, gastric, colorectal, lung, brain, and head and neck tumors. However, the advent of next-generation sequencing technologies has enabled efficient identification of activating molecular alterations of ERBB2. In this review, we will focus on the functional role of these somatic mutations that cause ERBB2 receptor activation. We will additionally discuss the current preclinical and clinical therapeutic strategies for targeting mutationally activated ERBB2

Microdissection of human chromosomes by a laser microbeam

A laser microbeam apparatus, based on an excimer laser pumped dye laser is used to microdissect human chromosomes and to isolate a single chromosome slice

Teaching Ethical Decision-Making in Counselor Education

How and when counseling graduate students are taught to apply ethical codes and principles varies. In this article the authors review foundational concepts and proposed practices for ethics education in graduate counseling programs. The authors present strategies for teaching ethical decision-making that focus on the intersection of personal values, principle and virtue ethics, and self-reflection. Recommendations are provided for content delivery and activities and assignments that encourage self-reflection of values in conjunction with the application of decision-making skills and models. Implications for future research are addressed

Teaching Ethical Decision-Making in Counselor Education

How and when counseling graduate students are taught to apply ethical codes and principles varies. In this article the authors review foundational concepts and proposed practices for ethics education in graduate counseling programs. The authors present strategies for teaching ethical decision-making that focus on the intersection of personal values, principle and virtue ethics, and self-reflection. Recommendations are provided for content delivery and activities and assignments that encourage self-reflection of values in conjunction with the application of decision-making skills and models. Implications for future research are addressed

The Subjective Cost of Young Children: A European Comparison

Understanding child-related costs is crucial given their impact on fertility and labour supply decisions. We explore the subjective cost of young children in Europe by analysing the effect of child births on parents’ self-reported ability to make ends meet, and link it to changes in objective economic well-being such as income, benefits, and employment. The study is based on EU-SILC longitudinal data for 30 European countries from 2004 to 2019, enabling comparisons between country groups of different welfare regimes. Results show that newborns decrease subjective economic well-being in all regions, yet with economies of scale for the number of children. Mediation analyses reveal that the substantial labour income losses of mothers (indirect costs) explain only a small part of subjective child costs. In the first year after birth, these losses are mostly compensated for via public transfers or increased labour income of fathers, except in regions where women take extensive parental leave. This suggests that the initial drop in subjective economic well-being after childbirth is caused by increased expenses due to the birth of a child (direct costs) and other drivers such as stress that are reflected in the self-reported indicator

The Subjective Cost of Young Children: A European Comparison

Understanding child-related costs is crucial given their impact on fertility and labour supply decisions. We quantify and compare the cost of children in Europe by analysing the effect of child births on parents’ self-reported ability to make ends meet. This study is based on EUSILC longitudinal data for 30 European countries from 2004 to 2015, enabling comparisons between country groups of different welfare regimes. Results show that newborns decrease subjective economic wellbeing in all regions, yet with economies of scale in the number of children. The drop is mainly caused by increased expenses due to the birth of a child (direct costs), which are largest in high-income regions. Immediate labour income losses of mothers (indirect costs) are less important in explaining the decrease. These income losses are closely related to the employment patterns of mothers and are highest in regions where women take extensive parental leave. In the first years after the birth, indirect costs are mostly compensated for via public transfers or increased labour income of fathers, while direct costs of children are not compensated for

The subjective cost of young children: A European comparison

Understanding child-related costs is crucial given their impact on fertility and labour supply decisions. We quantify and compare the cost of children in Europe by analysing the effect of child births on parents’ self-reported ability to make ends meet. This study is based on EU- SILC longitudinal data for 30 European countries from 2004 to 2015, enabling comparisons between country groups of different welfare regimes. Results show that newborns decrease subjective economic wellbeing in all regions, yet with economies of scale in the number of children. The drop is mainly caused by increased expenses due to the birth of a child (direct costs), which are largest in high-income regions. Immediate labour income losses of mothers (indirect costs) are less important in explaining the decrease. These income losses are closely related to the employment patterns of mothers and are highest in regions where women take extensive parental leave. In the first years after the birth, indirect costs are mostly compensated for via public transfers or increased labour income of fathers, while direct costs of children are not compensated for

Particle interactions and lattice dynamics: Scenarios for efficient bidirectional stochastic transport?

Intracellular transport processes driven by molecular motors can be described by stochastic lattice models of self-driven particles. Here we focus on bidirectional transport models excluding the exchange of particles on the same track. We explore the possibility to have efficient transport in these systems. One possibility would be to have appropriate interactions between the various motors' species, so as to form lanes. However, we show that the lane formation mechanism based on modified attachment/detachment rates as it was proposed previously is not necessarily connected to an efficient transport state and is suppressed when the diffusivity of unbound particles is finite. We propose another interaction mechanism based on obstacle avoidance that allows to have lane formation for limited diffusion. Besides, we had shown in a separate paper that the dynamics of the lattice itself could be a key ingredient for the efficiency of bidirectional transport. Here we show that lattice dynamics and interactions can both contribute in a cooperative way to the efficiency of transport. In particular, lattice dynamics can decrease the interaction threshold beyond which lanes form. Lattice dynamics may also enhance the transport capacity of the system even when lane formation is suppressed.Comment: 25 pages, 17 figures, 2 table

2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry

Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events